One of the easiest way to shoot a good pic is to get a hotel with a good view. You can spend a lot of time setting up your camera, etc. Do your research before booking your hotel room. I shot this with "in-camera HDR" mode. It was handheld and got as close as possible to the window to reduce glare. This was taken from a hotel room of Hyatt on Riverwalk. (Sony a7, FE28-70mm f/3.5-5.6OSS at 34mm f/4.0 at 1/60)